Propanamide, N-(3-chloro-2-hydroxyphenyl)-

Base Information

• Chemical Name: Propanamide, N-(3-chloro-2-hydroxyphenyl)-
• CAS No.: 221291-87-8
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• DSSTox Substance ID: DTXSID00458704
• Nikkaji Number: J1.646.066D
• Wikidata: Q82282190
• Mol file: 221291-87-8.mol

Synonyms:Propanamide, N-(3-chloro-2-hydroxyphenyl)-;221291-87-8;N-(3-Chloro-2-hydroxyphenyl)propionamide;SCHEMBL12535510;DTXSID00458704

Chemical Property of Propanamide, N-(3-chloro-2-hydroxyphenyl)-

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.0400063
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NC1=C(C(=CC=C1)Cl)O

Technology Process of Propanamide, N-(3-chloro-2-hydroxyphenyl)-

There total 2 articles about Propanamide, N-(3-chloro-2-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propionyl chloride (79-03-8) + 2-amino-6-chlorophenol hydrochloride → N-(3-chloro-2-hydroxyphenyl)propionamide (221291-87-8)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2013.06.026

Reference yield:

2-chloro-6-nitrophenol (603-86-1) → N-(3-chloro-2-hydroxyphenyl)propionamide (221291-87-8)

Guidance literature:

Reference yield: 33.1%

N-(3-chloro-2-hydroxyphenyl)propionamide (221291-87-8) + isothiazolo[3,4-b]pyridin-3-amine (42242-06-8) → C15H12ClN5O2S

Guidance literature:

isothiazolo[3,4-b]pyridin-3-amine; With phosphoric acid; sodium nitrite; In water; at 5 ℃; for 0.5h;

N-(3-chloro-2-hydroxyphenyl)propionamide; With acetic acid; In water; at 10 ℃; for 5h;

upstream raw materials:

2-chloro-6-nitrophenol

propionyl chloride

Downstream raw materials:

N-(3-chloro-5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

N-(3-chloro-2-hydroxy-5-(((3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)phenyl)propionamide

N-(3-chloro-5-(((4-cyano-1,3-dimethyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide