5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester
• CAS No.: 940963-92-8
• Molecular Formula: C₄₃H₅₆N₈O₁₃
• Molecular Weight: 892.963

Synonyms:5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Chemical Property of 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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Technology Process of 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

There total 6 articles about 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-((S)-alanyl-O4-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-88-2) + 2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid (650609-89-5) → 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O4-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-92-8)

Guidance literature:

With 1-methyl-3-chloropyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo061918x

Reference yield:

5-(N2-benzyloxycarbonyl-O4-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-78-0) → 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O4-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-92-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / hydrogen / palladium on carbon / methanol / 16 h

2: 64 percent / HCTU; 6-chloro-1-hydroxy-1H-benzotriazole; 2,6-lutidine / CH₂Cl₂; dimethylformamide / 3.5 h

3: 87 percent / hydrogen / palladium on carbon / methanol / 16 h

4: 66 percent / 3-chloro-1-methylpyridinium iodide; ethyldiisopropylamine / CH₂Cl₂ / 16 h / 20 °C

With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); hydrogen; 1-methyl-3-chloropyridinium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo061918x

Reference yield:

5-(N-benzyloxycarbonyl-(S)-alanyl-O4-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-84-8) → 5-{5-[2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino]-2-(4-methoxybenzyl)-2H-pyrazolecarbonyl-(S)-alanyl-O4-tert-butyl-(S)-aspartyl-amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (940963-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / hydrogen / palladium on carbon / methanol / 16 h

2: 66 percent / 3-chloro-1-methylpyridinium iodide; ethyldiisopropylamine / CH₂Cl₂ / 16 h / 20 °C

With hydrogen; 1-methyl-3-chloropyridinium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jo061918x

upstream raw materials:

5-((S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

5-(O⁴-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

5-(N-benzyloxycarbonyl-(S)-alanyl-O⁴-tert-butyl-(S)-aspartyl-amino)-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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