(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Base Information

Chemical Name:(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1356332-01-8
Molecular Formula:C₂₆H₂₉N₃O₃
Molecular Weight:431.535
Hs Code.:

Synonyms:(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Suppliers and Price of (R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 10 articles about (R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356333-02-2
(R)-ethyl 7-(8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

: 1356332-01-8
(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: (R)-ethyl 7-(8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate; With water; lithium hydroxide; In tetrahydrofuran; for 4h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=5;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356332-01-8
(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3.1: dmap / tetrahydrofuran / 125 h / 20 °C

4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5.1: dichloromethane / 20 °C / Inert atmosphere

6.1: Chiralcel OJ-H / Resolution of racemate

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran / 4 h / Reflux

9.2: 20 °C / pH 5

With hydrogenchloride; N-Bromosuccinimide; water; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hydroxide; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 134-81-6
benzil

: 1356332-01-8
(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3.1: dmap / tetrahydrofuran / 125 h / 20 °C

4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5.1: dichloromethane / 20 °C / Inert atmosphere

6.1: Chiralcel OJ-H / Resolution of racemate

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran / 4 h / Reflux

9.2: 20 °C / pH 5

With hydrogenchloride; N-Bromosuccinimide; water; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hydroxide; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; 1,2-dichloro-ethane;