(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

Base Information

Chemical Name:(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester
CAS No.:1356332-57-4
Molecular Formula:C₂₁H₁₉N₃O₂
Molecular Weight:345.401
Hs Code.:

Synonyms:(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

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Chemical Property of (R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

Chemical Property:

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Technology Process of (R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

There total 8 articles about (R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-59-6
(R)-tert-butyl 8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

: 1356332-57-4
(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356332-57-4
(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3: dmap / tetrahydrofuran / 125 h / 20 °C

4: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5: dichloromethane / 20 °C / Inert atmosphere

6: Chiralcel OJ-H / Resolution of racemate

7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; hydrogen; acetic acid; triethylamine; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane;

Reference yield:

: 134-81-6
benzil

: 1356332-57-4
(R)-acetic acid 2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3: dmap / tetrahydrofuran / 125 h / 20 °C

4: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5: dichloromethane / 20 °C / Inert atmosphere

6: Chiralcel OJ-H / Resolution of racemate

7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; hydrogen; acetic acid; triethylamine; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane;