2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Base Information

Chemical Name:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde
CAS No.:1242156-60-0
Molecular Formula:C₁₉H₁₆ClFN₂O₂
Molecular Weight:358.8
Hs Code.:

Synonyms:2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Suppliers and Price of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

There total 13 articles about 2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.2%

: 1242156-59-7
6-(tert-butyl)-8-fluorophthalazin-1(2H)-one

: 387-45-1
2-chloro-6-fluorobenzaldehyde

: 1242156-60-0
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Guidance literature:: With ethyl trimethylsilyl ether; caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h; Inert atmosphere of nitrogen;

Reference yield:

: 438481-01-7
4-(tert-butyl)-N-(1-hydroxy-2-methylpropan-2-yl)benzamide

: 1242156-60-0
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 1 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - -20 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C

3.1: pyridinium p-toluenesulfonate / toluene / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - -17 °C / Inert atmosphere

4.2: 1.5 h / -78 - 20 °C

5.1: sulfuric acid / methanol; water / Reflux

6.1: hydrazine hydrate / acetic acid / 1.5 h / 50 °C / Inert atmosphere

7.1: ethyl trimethylsilyl ether; caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; ethyl trimethylsilyl ether; sulfuric acid; pyridinium p-toluenesulfonate; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; methanol; hexane; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 150943-13-8
2-(4-tert-butyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1242156-60-0
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-chlorobenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 - -20 °C / Inert atmosphere

1.2: 2.25 h / -78 - 20 °C

2.1: pyridinium p-toluenesulfonate / toluene / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - -17 °C / Inert atmosphere

3.2: 1.5 h / -78 - 20 °C

4.1: sulfuric acid / methanol; water / Reflux

5.1: hydrazine hydrate / acetic acid / 1.5 h / 50 °C / Inert atmosphere

6.1: ethyl trimethylsilyl ether; caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

With n-butyllithium; ethyl trimethylsilyl ether; sulfuric acid; pyridinium p-toluenesulfonate; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; methanol; hexane; water; acetic acid; N,N-dimethyl-formamide; toluene;