1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

Base Information

Chemical Name:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril
CAS No.:374694-94-7
Molecular Formula:C₂₉H₂₀Cl₂N₂O₆
Molecular Weight:563.394
Hs Code.:

Synonyms:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

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Chemical Property of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

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Technology Process of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

There total 4 articles about 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 557-21-1
dicyanozinc

: 374694-90-3
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

: 374694-94-7
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 6h;
DOI:10.1081/NCN-100105246

Reference yield:

: 491-30-5
1-isoquinolone

: 374694-94-7
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 84 percent / (Ph₃P)4Pd / dimethylformamide / 6 h / 80 - 90 °C

With N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1081/NCN-100105246

Reference yield:

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 374694-94-7
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 84 percent / (Ph₃P)4Pd / dimethylformamide / 6 h / 80 - 90 °C

With N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1081/NCN-100105246