1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

Base Information

• Chemical Name: 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril
• CAS No.: 374694-90-3
• Molecular Formula: C₂₈H₂₀Cl₂INO₆
• Molecular Weight: 664.28

Synonyms:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

Chemical Property of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

There total 3 articles about 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]isocarbostyril (374694-86-7) → 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril (374694-90-3)

Guidance literature:

With Iodine monochloride; In dichloromethane; Heating;

DOI:10.1081/NCN-100105246

Reference yield:

1-isoquinolone (491-30-5) → 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril (374694-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

With N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; In dichloromethane; acetonitrile;

DOI:10.1081/NCN-100105246

Reference yield:

3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride (21740-23-8) → 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril (374694-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

With N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; In dichloromethane; acetonitrile;

DOI:10.1081/NCN-100105246

upstream raw materials:

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]isocarbostyril

1-isoquinolone

3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

Downstream raw materials:

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-cyanoisocarbostyril

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoethynylisocarbostyril

1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-(2-bromoethynyl)isocarbostyril

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