(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

Base Information

Chemical Name:(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole
CAS No.:170305-69-8
Molecular Formula:C₂₀H₃₁N₃O₂Si
Molecular Weight:373.571
Hs Code.:

Synonyms:(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

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Chemical Property of (2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

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Technology Process of (2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

There total 2 articles about (2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 170305-65-4
(2'S)-<1-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)pyrrolidin-2'-yl>methanol

: 170305-69-8
(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 1822-94-2
5-(chloromethyl)-3-phenyl-1,2,4-oxadiazole

: 170305-69-8
(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Et₃N / ethanol / 3 h / Heating

2: 93 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield: 90.0%

: 100-52-7
benzaldehyde

: 170305-69-8
(2'S)-5-(2'-tert-Butyldimethylsilyloxymethylpyrrolidin-1-ylmethyl)-3-phenyl-1,2,4-oxadiazole

: (2'RS,2''S)-2'-(2''-tert-Butyldimethylsilyloxymethylpyrrolidin-1-yl)-1-phenyl-2'-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.) -78 deg C, 1 h, 2.) -100 deg C, 1 h; -100 deg C to r.t., overnight;