Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

Base Information

Chemical Name:Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate
CAS No.:937054-56-3
Molecular Formula:C₂₆H₂₈ClNO₅
Molecular Weight:469.965
Hs Code.:

Synonyms:Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

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Chemical Property of Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

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Technology Process of Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

There total 5 articles about Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937057-77-7
C₂₆H₃₀ClNO₆

: 937054-56-3
Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

Guidance literature:: C₂₆H₃₀ClNO₆; With phosphorus pentoxide; In toluene; at 80 ℃; for 3h;

With water; sodium hydrogencarbonate; In ethyl acetate; toluene;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937054-56-3
Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: zinc / benzene / 1 h / Heating / reflux

2.2: 10 h / 0 °C

2.3: 1 h / 20 °C / Heating / reflux

3.1: sodium tetrahydroborate / methanol / 24 h / 20 °C

4.1: phosphorus pentoxide / toluene / 3 h / 80 °C

With sodium tetrahydroborate; phosphorus pentoxide; zinc; trichlorophosphate; In methanol; toluene; benzene;

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937054-56-3
Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc / benzene / 1 h / Heating / reflux

1.2: 10 h / 0 °C

1.3: 1 h / 20 °C / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 24 h / 20 °C

3.1: phosphorus pentoxide / toluene / 3 h / 80 °C

With sodium tetrahydroborate; phosphorus pentoxide; zinc; In methanol; toluene; benzene;