2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

Base Information

Chemical Name:2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid
CAS No.:937054-57-4
Molecular Formula:C₂₄H₂₄ClNO₅
Molecular Weight:441.911
Hs Code.:

Synonyms:2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

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Chemical Property of 2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

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Technology Process of 2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

There total 6 articles about 2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-56-3
Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate

: 937054-57-4
2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

Guidance literature:: Ethyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionate; With sodium hydroxide; water; isopropyl alcohol; at 80 ℃; for 4h;

With hydrogenchloride; water; at 0 ℃;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937054-57-4
2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: zinc / benzene / 1 h / Heating / reflux

2.2: 10 h / 0 °C

2.3: 1 h / 20 °C / Heating / reflux

3.1: sodium tetrahydroborate / methanol / 24 h / 20 °C

4.1: phosphorus pentoxide / toluene / 3 h / 80 °C

5.1: sodium hydroxide; water; isopropyl alcohol / 4 h / 80 °C

5.2: 0 °C

With sodium hydroxide; sodium tetrahydroborate; water; phosphorus pentoxide; isopropyl alcohol; zinc; trichlorophosphate; In methanol; toluene; benzene;

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937054-57-4
2-[8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc / benzene / 1 h / Heating / reflux

1.2: 10 h / 0 °C

1.3: 1 h / 20 °C / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 24 h / 20 °C

3.1: phosphorus pentoxide / toluene / 3 h / 80 °C

4.1: sodium hydroxide; water; isopropyl alcohol / 4 h / 80 °C

4.2: 0 °C

With sodium hydroxide; sodium tetrahydroborate; water; phosphorus pentoxide; isopropyl alcohol; zinc; In methanol; toluene; benzene;