Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

Base Information

Chemical Name:Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate
CAS No.:937057-76-6
Molecular Formula:C₂₆H₂₈ClNO₆
Molecular Weight:485.964
Hs Code.:

Synonyms:Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

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Chemical Property of Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

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Technology Process of Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

There total 3 articles about Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937057-76-6
Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

Guidance literature:: ethyl 2-bromoisobutyrate; With zinc; In benzene; for 1h; Heating / reflux;

1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde; In benzene; at 0 ℃; for 10h;

With iodine; In benzene; at 20 ℃; for 1h; Heating / reflux;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937057-76-6
Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: zinc / benzene / 1 h / Heating / reflux

2.2: 10 h / 0 °C

2.3: 1 h / 20 °C / Heating / reflux

With zinc; trichlorophosphate; In benzene;

Reference yield:

: 152911-43-8
(2-amino-5-chlorophenyl)(2,3-dimethoxyphenyl)methanone

: 937057-76-6
Ethyl 3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrol-2-yl}-3-hydroxy-2,2-dimethylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.5 h / Heating / reflux

2.1: trichlorophosphate / 0.17 h / 0 - 20 °C

2.2: 2 h / 50 °C / Heating / reflux

2.3: 0.5 h / Heating / reflux

3.1: zinc / benzene / 1 h / Heating / reflux

3.2: 10 h / 0 °C

3.3: 1 h / 20 °C / Heating / reflux

With acetic acid; zinc; trichlorophosphate; In benzene;