[6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine

Base Information

• Chemical Name: [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine
• CAS No.: 1346163-77-6
• Molecular Formula: C₂₆H₂₂N₄O₄S
• Molecular Weight: 486.551
• Mol file: 1346163-77-6.mol

Synonyms:[6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine

Chemical Property of [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine

There total 2 articles about [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole (1346163-38-9) + 4-methoxy-aniline (104-94-9) → [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine (1346163-77-6)

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield:

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole (722538-29-6) → [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine (1346163-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

2: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1: Stille cross-coupling / 2: Buchwald-Hartwig cross-coupling;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield: 86.0%

[6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine (1346163-77-6) → [6-(5-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxyphenyl)-amine

Guidance literature:

[6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 12h; Reflux;

With water;

DOI:10.1016/j.ejmech.2011.08.048

upstream raw materials:

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

4-methoxy-aniline

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole