1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

Base Information

• Chemical Name: 1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole
• CAS No.: 1346163-38-9
• Molecular Formula: C₁₉H₁₄ClN₃O₃S
• Molecular Weight: 399.857
• Mol file: 1346163-38-9.mol

Synonyms:1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

Chemical Property of 1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

There total 1 articles about 1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole (722538-29-6) + 2,6-dichloropyrazine (4774-14-5) → 1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole (1346163-38-9)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 100 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield: 86.0%

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole (1346163-38-9) + 4-methoxy-aniline (104-94-9) → [6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-(4-methoxy-phenyl)-amine (1346163-77-6)

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.08.048

Reference yield: 73.0%

1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole (1346163-38-9) + 4-cyanophenylboronic acid (126747-14-6) → 4-[6-(1-benzenesulfonyl-6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-benzonitrile (1346163-40-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; toluene; at 150 ℃; for 0.25h; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.08.048

upstream raw materials:

1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole

2,6-dichloropyrazine

Downstream raw materials:

6-methoxy-2-[6-(4-methoxy-phenyl)-pyrazin-2-yl]-1H-indole

4-[6-(6-methoxy-1H-indol-2-yl)-pyrazin-2-yl]-benzonitrile

2-[6-(4-methanesulfonyl-phenyl)-pyrazin-2-yl]-6-methoxy-1H-indole

2-[6-(4-hydroxy-phenyl)-pyrazin-2-yl]-1H-indol-6-ol