5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone

Base Information

• Chemical Name: 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone
• CAS No.: 121082-76-6
• Molecular Formula: C₁₂H₁₅NO₆S
• Molecular Weight: 301.32
• Mol file: 121082-76-6.mol

Synonyms:5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone

Chemical Property of 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone

There total 6 articles about 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-(hydroxy-methyl)-3-p-methoxyphenyl-2-oxazolidinone (42902-32-9) + methanesulfonyl chloride (124-63-0) → 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone (121082-76-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

3-<(4-methoxyphenyl)amino>-1,2-propanediol (121082-77-7) → 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone (121082-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: TEA / CH₂Cl₂ / 0 °C

With TEA; In dichloromethane; toluene;

DOI:10.1021/jm00075a015

Reference yield:

4-methoxy-aniline (104-94-9) → 5-(methanesulfonyloxymethyl)-3-p-methoxyphenyl-2-oxazolidinone (121082-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 31 percent / methanol / 1.) 50 deg C, 12 h, 2.) reflux, 12 h

2: 83 percent / sodium methoxide / toluene; methanol / 3 h / 105 °C

3: 93 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With sodium methylate; triethylamine; In methanol; dichloromethane; toluene;

upstream raw materials:

5-(hydroxy-methyl)-3-p-methoxyphenyl-2-oxazolidinone

methanesulfonyl chloride

3-<(4-methoxyphenyl)amino>-1,2-propanediol

4-methoxy-aniline

Downstream raw materials:

3-(4-methoxyphenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one

3-(4-methoxyphenyl)-5-[4-(3-indolyl)-1-piperidinylmethyl]oxazolidin-2-one

3-(4-methoxyphenyl)-5-<(N-methylamino)methyl>-2-oxazolidinone

5-<(N,N-dimethylamino)methyl>-3-(4-methoxyphenyl)-2-oxazolidinone