naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Base Information

Chemical Name:naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide
CAS No.:905575-45-3
Molecular Formula:C₄₀H₃₈N₄O₃
Molecular Weight:622.767
Hs Code.:

Synonyms:naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Suppliers and Price of naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

There total 6 articles about naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 905575-42-0
naphthalene-1-carboxylic acid (4-piperazin-1-yl-biphenyl-3-yl)-amide

: 954-81-4
N-(5-bromopentyl)phthalimide

: 905575-45-3
naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Guidance literature:: With potassium carbonate; In acetonitrile; for 10h; Heating;
DOI:10.1021/jm0602864

Reference yield:

: 883908-27-8
1-benzyl-4-(2-amino-4-bromo-phenyl)-piperazine

: 905575-45-3
naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / DIEA / CH₂Cl₂ / 4 h / 20 °C

2: 80 percent / dppf; KOAc / dppf-Pd(II) / dioxane / 72 h / Heating

3: 88 percent / ammonium formate / Pd/C / methanol / 6 h / Heating

4: 99 percent / K₂CO₃ / acetonitrile / 10 h / Heating

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; dppf-Pd(II); In 1,4-dioxane; methanol; dichloromethane; acetonitrile; 2: Suzuki cross-coupling;
DOI:10.1021/jm0602864

Reference yield:

: 883522-59-6
1-benzyl-4-(4-bromo-2-nitro-phenyl)-piperazine

: 905575-45-3
naphthalene-1-carboxylic acid (4-{4-[5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-piperazin-1-yl}-biphenyl-3-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

2: 75 percent / DIEA / CH₂Cl₂ / 4 h / 20 °C

3: 80 percent / dppf; KOAc / dppf-Pd(II) / dioxane / 72 h / Heating

4: 88 percent / ammonium formate / Pd/C / methanol / 6 h / Heating

5: 99 percent / K₂CO₃ / acetonitrile / 10 h / Heating

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium dihydrogenphosphate; potassium acetate; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; dppf-Pd(II); In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile; 3: Suzuki cross-coupling;
DOI:10.1021/jm0602864