6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

Base Information

Chemical Name:6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde
CAS No.:957115-13-8
Molecular Formula:C₂₀H₁₄Cl₂FNO₂
Molecular Weight:390.241
Hs Code.:

Synonyms:6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

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Chemical Property of 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

Chemical Property:

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Technology Process of 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

There total 4 articles about 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinyl}methanol

: 957115-13-8
6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 41337-81-9
ethyl 6-(hydroxymethyl)pyridine-2-carboxylate

: 957115-13-8
6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 1.25 h / 10 - 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 1 - 6 h / 80 - 90 °C

3.1: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 20 °C / Heating / reflux

3.2: 20 °C

4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With lithium borohydride; thionyl chloride; potassium carbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 49668-99-7
ethyl 6-chloromethylpyridine-2-carboxylate

: 957115-13-8
6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 1 - 6 h / 80 - 90 °C

2.1: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 20 °C / Heating / reflux

2.2: 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With lithium borohydride; potassium carbonate; Dess-Martin periodane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;