diphenyl(quinolin-8-yl)phosphine oxide

Base Information

• Chemical Name: diphenyl(quinolin-8-yl)phosphine oxide
• CAS No.: 1253596-50-7
• Molecular Formula: C₂₁H₁₆NOP
• Molecular Weight: 329.338
• Mol file: 1253596-50-7.mol

Synonyms:diphenyl(quinolin-8-yl)phosphine oxide

Chemical Property of diphenyl(quinolin-8-yl)phosphine oxide

Chemical Property:

Purity/Quality:

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Technology Process of diphenyl(quinolin-8-yl)phosphine oxide

There total 6 articles about diphenyl(quinolin-8-yl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

8-quinolinol (148-24-3,24804-14-6) + Diphenylphosphine oxide (4559-70-0) → diphenyl(quinolin-8-yl)phosphine oxide (1253596-50-7)

Guidance literature:

8-quinolinol; With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In acetonitrile; at 100 ℃; for 3h; Inert atmosphere;

Diphenylphosphine oxide; With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In acetonitrile; at 120 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c2cc31718d

Reference yield: 86.0%

8-chloroquinoline (611-33-6) + Diphenylphosphine oxide (4559-70-0) → diphenyl(quinolin-8-yl)phosphine oxide (1253596-50-7)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c2ob26874d

Reference yield: 83.0%

toluene-4-sulfonic acid quinolin-8-yl ester (10522-42-6) + Diphenylphosphine oxide (4559-70-0) → diphenyl(quinolin-8-yl)phosphine oxide (1253596-50-7)

Guidance literature:

With pyridine; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine; In tetrahydrofuran; toluene; at 50 ℃; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1177/1747519821994533

upstream raw materials:

8-(diphenylphosphino)quinoline

8-quinolinol

Diphenylphosphine oxide

8-chloroquinoline

Downstream raw materials:

[Cu(diphenyl(8-quinolyl)phosphane oxide)(bis-[2-(diphenylphosphanyl)phenyl] ether)][BF₄]