Technology Process of (RS)-22-<2'-(Methoxymethoxy)phenyl>-docosan-2-ol
There total 12 articles about (RS)-22-<2'-(Methoxymethoxy)phenyl>-docosan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
nickel;
In
ethyl acetate;
for 3h;
under 3000.2 Torr;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / SOCl2 / 1 h / Heating
2: 85 percent / 2-mercaptopyridine-N-oxide, Et3N, CBrCl3 / CH2Cl2 / 4.17 h / Ambient temperature; Irradiation
3: 1.) Hg(OAc)2; 2.) NaBH4 / 1.) H2O, THF, 30 min.; 2.) H2O, aq. NaOH, THF, 1 h
4: 95 percent / acetonitrile / 52 h / Heating
5: 97 percent / 80 percent NaH / dimethylsulfoxide; tetrahydrofuran / 15 h / Ambient temperature
6: 99 percent / H2 / Raney-Nickel / ethyl acetate / 3 h / 3000.2 Torr / Ambient temperature
With
sodium tetrahydroborate; thionyl chloride; Bromotrichloromethane; mercury(II) diacetate; hydrogen; sodium hydride; triethylamine; 2-mercaptopyridine N-oxide;
nickel;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / 48 percent aqueous HBr / 12 h / 80 - 90 °C / darkness
2: 85 percent / pyridinium-p-toluenesulfonate / CH2Cl2 / 12 h / Ambient temperature
3: 85 percent / 2.5 M BuLi, N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran
4: 1.) pyridinium p-toluenesulfonate; 2.) 80 percent MCPBA
5: oxalic acid dichloride / dimethylsulfoxide
6: 97 percent / 80 percent NaH / dimethylsulfoxide; tetrahydrofuran / 15 h / Ambient temperature
7: 99 percent / H2 / Raney-Nickel / ethyl acetate / 3 h / 3000.2 Torr / Ambient temperature
With
n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; hydrogen bromide; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
nickel;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate;
