(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

Base Information

Chemical Name:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate
CAS No.:154520-21-5
Molecular Formula:C₃₃H₄₈N₂O₄S
Molecular Weight:568.821
Hs Code.:

Synonyms:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

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Technology Process of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

There total 3 articles about (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75-03-6
ethyl iodide

: (2RS)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-phenyl-2-cyanoacetate

: 154520-21-5
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

: 171038-14-5
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

Guidance literature:: With lithium diisopropyl amide; Yields of byproduct given; 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d;
DOI:10.1021/jo00088a034

Reference yield:

: 30698-30-7
methyl 2-cyano-2-phenylacetate

: 154520-21-5
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / AlMe₃ / toluene; hexane / 1.) r.t., 30 min, 2.) 80 deg C, 8 h

2: 85 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With trimethylaluminum; lithium diisopropyl amide; In hexane; toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 154520-21-5
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / AlMe₃ / toluene; hexane / 1.) r.t., 30 min, 2.) 80 deg C, 8 h

2: 85 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With trimethylaluminum; lithium diisopropyl amide; In hexane; toluene;
DOI:10.1021/jo00088a034