tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate
CAS No.:1301610-79-6
Molecular Formula:C₂₂H₂₃IN₂O₃
Molecular Weight:490.341
Hs Code.:

Synonyms:tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Suppliers and Price of tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Technology Process of tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

There total 4 articles about tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1301610-78-5
tert-butyl (1-(4-((2-methoxypyridin-3-yl)ethynyl)phenyl)cyclobutyl)carbamate

: 1301610-79-6
tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: tert-butyl (1-(4-((2-methoxypyridin-3-yl)ethynyl)phenyl)cyclobutyl)carbamate; With Iodine monochloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With sodium thiosulfate; In dichloromethane; water;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1301610-79-6
tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 20 - 80 °C / Inert atmosphere

2: potassium carbonate; methanol / 1 h

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 3 h / 0 - 20 °C / Inert atmosphere

4: Iodine monochloride / dichloromethane / 0 °C / Inert atmosphere

With methanol; Iodine monochloride; potassium carbonate; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1301610-33-2
tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate

: 1301610-79-6
tert-butyl (1-(4-(3-iodofuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 3 h / 0 - 20 °C / Inert atmosphere

2: Iodine monochloride / dichloromethane / 0 °C / Inert atmosphere

With Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane;