1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine
CAS No.:1301608-93-4
Molecular Formula:C₂₃H₂₀N₂O
Molecular Weight:340.425
Hs Code.:

Synonyms:1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

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Technology Process of 1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

There total 6 articles about 1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1301610-80-9
tert-butyl (1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1301608-93-4
1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

Guidance literature:: tert-butyl (1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1301608-93-4
1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 20 - 80 °C / Inert atmosphere

2: potassium carbonate; methanol / 1 h

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 3 h / 0 - 20 °C / Inert atmosphere

4: Iodine monochloride / dichloromethane / 0 °C / Inert atmosphere

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With methanol; Iodine monochloride; sodium carbonate; potassium carbonate; triethylamine; diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1301610-33-2
tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate

: 1301608-93-4
1-(4-(3-phenylfuro[2,3-b]pyridin-2-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 3 h / 0 - 20 °C / Inert atmosphere

2: Iodine monochloride / dichloromethane / 0 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With Iodine monochloride; sodium carbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene;