4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

Base Information

Chemical Name:4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione
CAS No.:146885-37-2
Molecular Formula:C₂₁H₂₂N₄S
Molecular Weight:362.498
Hs Code.:

Synonyms:4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

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Chemical Property of 4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

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Technology Process of 4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

There total 5 articles about 4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 146885-36-1
ethyl hexanoate 4-<(2'-cyanobiphenyl-4-yl)methyl>thiosemicarbazone

: 146885-37-2
4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 30h; Heating;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 146885-37-2
4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / lithium azide / dimethylsulfoxide / 1 h / Ambient temperature

2: triphenylphosphine / 5.5 h / Ambient temperature

3: hydrazine hydrate / tetrahydrofuran / 0.17 h

4: 50 percent / dimethylformamide / 1.5 h / Ambient temperature

5: 67 percent / DBU / tetrahydrofuran / 30 h / Heating

With lithium azide; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-91-2
4'-(azidomethyl)[1,1'-biphenyl]-2-carbonitrile

: 146885-37-2
4-<(2'-cyanobiphenyl-4-yl)methyl>-2,4-dihydro-5-n-pentyl-3H-1,2,4-triazole-3-thione

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / 5.5 h / Ambient temperature

2: hydrazine hydrate / tetrahydrofuran / 0.17 h

3: 50 percent / dimethylformamide / 1.5 h / Ambient temperature

4: 67 percent / DBU / tetrahydrofuran / 30 h / Heating

With hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00057a009