Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

Base Information

Chemical Name:Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate
CAS No.:947537-62-4
Molecular Formula:C₂₆H₄₂N₂O₁₁P₂
Molecular Weight:620.574
Hs Code.:

Synonyms:Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

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Chemical Property of Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

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Technology Process of Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

There total 3 articles about Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 947537-61-3
3-((1-((benzyloxy)carbonyl)piperidin-4-yloxy)carbonyl)propanoic acid

: 80474-99-3
tetraethyl (aminomethylene)bis(phosphonate)

: 947537-62-4
Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 947537-62-4
Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / chloroform / 24 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; chloroform;

Reference yield:

: 80474-97-1
tetraethyl (N,N-dibenzyl)aminomethyl-bis(phosphonate)

: 947537-62-4
Tetraethyl (4-(1-(benzyloxycarbonyl)-piperidin-4-yloxy)-4-oxo-butanoyl-amino)methylene-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: cyclohexene / palladium 10% on activated carbon / ethanol / 15 h / Reflux; Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cyclohexene; dmap; palladium 10% on activated carbon; In ethanol; dichloromethane;