(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Base Information

Chemical Name:(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester
CAS No.:1359172-36-3
Molecular Formula:C₃₉H₄₆ClNO₃SSi
Molecular Weight:672.404
Hs Code.:

(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Synonyms:(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

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Chemical Property of (1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

There total 9 articles about (1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359172-40-9
C₇H₁₁O₂S^(1-)*Cs⁽¹⁺⁾

: 1359172-33-0
C₃₃H₃₈ClNO₄SSi

: 1359172-36-3
(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 149968-10-5
(E)-3-<2-(7-chloro-2-quinolinyl)ethenyl>-α-ethenylphenylmethanol

: 1359172-36-3
(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate; tetrabutylammomium bromide / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran / 20 °C

3: benzo[1,3,2]dioxaborole; (R)-2-(o-methyl)phenyl-CBS-oxazaborolidine / dichloromethane / -50 - -40 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C

5: 1-methyl-pyrrolidin-2-one / 0 - 20 °C / Inert atmosphere

With (R)-2-(o-methyl)phenyl-CBS-oxazaborolidine; 1H-imidazole; tetrabutylammomium bromide; sodium acetate; triethylamine; benzo[1,3,2]dioxaborole; palladium diacetate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

: 7073-69-0
2-(2-bromophenyl)propanol

: 1359172-36-3
(1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate; tetrabutylammomium bromide / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere

2: 1H-imidazole / tetrahydrofuran / 20 °C

3: benzo[1,3,2]dioxaborole; (R)-2-(o-methyl)phenyl-CBS-oxazaborolidine / dichloromethane / -50 - -40 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C

5: 1-methyl-pyrrolidin-2-one / 0 - 20 °C / Inert atmosphere

With (R)-2-(o-methyl)phenyl-CBS-oxazaborolidine; 1H-imidazole; tetrabutylammomium bromide; sodium acetate; triethylamine; benzo[1,3,2]dioxaborole; palladium diacetate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;