[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

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Chemical Name:[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol
CAS No.:1221784-96-8
Molecular Formula:C₂₀H₁₄F₁₂N₂O
Molecular Weight:526.325
Hs Code.:

Synonyms:[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

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Chemical Property of [6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

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Technology Process of [6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

There total 4 articles about [6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221784-94-6
6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinic acid

: 1221784-96-8
[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

Guidance literature:: 6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)nicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 5h;

With sodium tetrahydroborate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 261635-79-4
methyl 6-chloro-4-(trifluoromethyl)pyridine-3-carboxylate

: 1221784-96-8
[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 24 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

3.2: 2 h / 0 - 20 °C

With oxalyl dichloride; water; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1072916-29-0
3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidine

: 1221784-96-8
[6-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoromethyl)pyridin-3-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 24 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

3.2: 2 h / 0 - 20 °C

With oxalyl dichloride; water; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide;