1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Base Information

Chemical Name:1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt
CAS No.:1287752-37-7
Molecular Formula:BrH*C₁₈H₁₈FNOS
Molecular Weight:396.323
Hs Code.:

Synonyms:1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

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Chemical Property of 1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

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Technology Process of 1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

There total 8 articles about 1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.1%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

: 1287752-37-7
1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Guidance literature:: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride; With potassium hydrogencarbonate; at 20 ℃; for 0.5h;

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; In acetonitrile; at 20 ℃; for 25h;

With hydrogen bromide; In water; acetone; at 10 - 20 ℃; for 3h; Reagent/catalyst;

Reference yield:

: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 1287752-37-7
1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Guidance literature:: With hydrogen bromide; In water; acetone; at 0 - 30 ℃; for 5h;

Reference yield:

: 150322-73-9
1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 1287752-37-7
1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone hydrobromide salt

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux

2: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C

3: hydrogen bromide / water; acetone / 5 h / 0 - 30 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; In chloroform; water; acetone; acetonitrile;