2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

Base Information

• Chemical Name: 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
• CAS No.: 204205-33-4
• Molecular Formula: C11H10BrFO
• Molecular Weight: 257.102
• Mol file: 204205-33-4.mol

Synonyms:2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone;Ethanone,2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-;a-(Cyclopropylcarbonyl)-2-fluorobenzyl bromide;

Chemical Property of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.592
• Boiling Point: 293.012 °C at 760 mmHg
• Flash Point: 131.009 °C
• PSA: 17.07000
• Density: 1.574 g/cm³
• LogP: 3.24080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Sparingly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-?Bromo-?2-?(2-?fluorophenyl)?-?1-?cyclopropylethanone(90%purity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-?Bromo-?2-?(2-?fluorophenyl)?-?1-?cyclopropylethanone is a reagent used in the synthesis of potent anti-oxidant agents.

Technology Process of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

There total 11 articles about 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

1-cyclopropyl-2-(2-fluorophenyl)ethanone (150322-73-9) → 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone (204205-33-4)

Guidance literature:

With iodine(I) bromide; 1-n-butyl-3-methylimidazolim bromide; In tetrahydrofuran; at 40 ℃; for 4h; Temperature; Time; Concentration;

Reference yield:

ethyl cyclopropylcarboxylate (4606-07-9) → 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone (204205-33-4)

Guidance literature:

With iodine; magnesium; isopropyl bromide; In tetrahydrofuran; at 65 ℃; for 3h;

ethyl cyclopropylcarboxylate; In tetrahydrofuran; at 5 - 70 ℃; for 3.16667h;

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); toluene-4-sulfonic acid; In chloroform; at 28 - 65 ℃; for 4h;

Reference yield:

2-(2-fluorophenyl)-N-methoxy-N-methylacetamide (946402-23-9) → 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone (204205-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C

1.2: 40 - 50 °C

1.3: 0.25 h / 0 - 30 °C

2.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); iodine; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; chloroform;

upstream raw materials:

1-cyclopropyl-2-(2-fluorophenyl)ethanone

(2-fluorophenyl)acetic acid

2-(2-fluorophenyl)-N-methoxy-N-methylacetamide

2-fluorobenzyl chloride

Downstream raw materials:

5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF HIGH-PURITY PRASUGREL". Page/Page column 13. . Retrieved 2018/04/11.
• 2、 -. "Method for preparing antithrombotic drug prasugrel intermediate". Paragraph 0025; 0062-0064. . Retrieved 2017/04/03.