(RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine

Base Information

• Chemical Name: (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine
• CAS No.: 543692-64-4
• Molecular Formula: C₂₂H₂₆N₂S
• Molecular Weight: 350.528
• Mol file: 543692-64-4.mol

Synonyms:(RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine

Chemical Property of (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine

There total 7 articles about (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

(RS)-(+/-)-4-(N-benzylanilino)-6-isopropyl-5,6-dihydropyridine-2(1H)-thione (543692-65-5) + methyl iodide (74-88-4) → (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine (543692-64-4)

Guidance literature:

In chloroform; at 20 ℃; for 6h;

DOI:10.1016/S0040-4020(03)00082-6

Reference yield:

benzyl bromide (100-39-0) + (RS)-(+/-)-4-anilino-2,3-dihydro-2-isopropyl-6-methylthiopyridine (543692-59-7) → (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine (543692-64-4)

Guidance literature:

With sodium amide; In toluene; at 120 ℃; for 16h;

DOI:10.1016/S0040-4020(03)00082-6

Reference yield:

(RS)-(+/-)-5,6-dihydro-4-hydroxy-6-isopropylpyridine-2(1H)-thione → (RS)-(+/-)-4-(N-benzylanilino)-2,3-dihydro-2-isopropyl-6-methylthiopyridine (543692-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.1 percent / 8 h / 60 - 120 °C

2: 90.6 percent / CHCl₃ / 6 h / 20 °C

In chloroform;

DOI:10.1016/S0040-4020(03)00082-6

upstream raw materials:

benzyl bromide

(RS)-(+/-)-4-anilino-2,3-dihydro-2-isopropyl-6-methylthiopyridine

(RS)-(+/-)-4-(N-benzylanilino)-6-isopropyl-5,6-dihydropyridine-2(1H)-thione

methyl iodide