(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Base Information

Chemical Name:(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate
CAS No.:1352917-66-8
Molecular Formula:C₈H₇ClO₃*C₁₄H₂₁NO
Molecular Weight:405.922
Hs Code.:

Synonyms:(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Suppliers and Price of (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Chemical Property:

Density:1.21g/cm3 at 20℃

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

There total 5 articles about (S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 10421-85-9,52923-23-6,52950-19-3,52950-18-2
(R)-2-chloromandelic acid

: 3904-24-3
(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride

: 1352917-66-8
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Guidance literature:: (5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propylamine hydrochloride; With triethylamine; In water; ethyl acetate; for 0.75h; Reflux;

(R)-2-chloromandelic acid; at 50 - 60 ℃; for 4h;

Reference yield: 34.0%

: 10421-85-9,52923-23-6,52950-19-3,52950-18-2
(R)-2-chloromandelic acid

: 78598-91-1,3899-07-8
2-(N-propylamino)-5-methoxytetraline

: 1352917-66-8
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Guidance literature:: In ethyl acetate; at 55 - 60 ℃; for 4h; Solvent; Temperature; Time;

Reference yield:

: 3880-88-4,58349-15-8,58349-17-0
SKF 87967 hydrochloride

: 1352917-66-8
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-naphthalen-2-ammonium (R)-2-(2-chlorophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 0 - 10 °C

1.2: 0.5 h / 0 - 20 °C

1.3: 1.33 h / 10 - 50 °C

2.1: potassium carbonate / 2-methyltetrahydrofuran / Reflux

3.1: methyltretrahydrofuran, 2- / 75 °C

With sodium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; methyltretrahydrofuran, 2-;