methyl 2-benzyl-2,8-dicyanooctanoate

Base Information

Chemical Name:methyl 2-benzyl-2,8-dicyanooctanoate
CAS No.:1360557-50-1
Molecular Formula:C₁₈H₂₂N₂O₂
Molecular Weight:298.385
Hs Code.:

Synonyms:methyl 2-benzyl-2,8-dicyanooctanoate

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Chemical Property of methyl 2-benzyl-2,8-dicyanooctanoate

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Technology Process of methyl 2-benzyl-2,8-dicyanooctanoate

There total 8 articles about methyl 2-benzyl-2,8-dicyanooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 17640-15-2
methyl cyanoformate

: 1360557-47-6
2-benzyl-8-chloro-2-(phenylsulfinyl)octanenitrile

: 1360557-50-1
methyl 2-benzyl-2,8-dicyanooctanoate

Guidance literature:: 2-benzyl-8-chloro-2-(phenylsulfinyl)octanenitrile; With n-butyllithium; diethylzinc; In tetrahydrofuran; hexane; at 0 ℃;

methyl cyanoformate; In tetrahydrofuran; hexane; at 20 ℃; for 2h;
DOI:10.1002/chem.201203174

Reference yield: 62.0%

: 17640-15-2
methyl cyanoformate

: 1510799-57-1
2-benzyl-2-(pyridin-2-ylthio)nonanedinitrile

: 1360557-50-1
methyl 2-benzyl-2,8-dicyanooctanoate

Guidance literature:: With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;
DOI:10.1021/ol403020s

Reference yield:

: 100-39-0
benzyl bromide

: 1360557-50-1
methyl 2-benzyl-2,8-dicyanooctanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

2.2: 6 h / -78 - 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.08 h / -78 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / -78 - 20 °C

With n-butyllithium; isopropylmagnesium chloride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/anie.201105630