methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate

Base Information

• Chemical Name: methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate
• CAS No.: 1417730-34-7
• Molecular Formula: C₁₈H₁₇NO₆S
• Molecular Weight: 375.402
• Mol file: 1417730-34-7.mol

Synonyms:methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate

Chemical Property of methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate

There total 6 articles about methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 6-(hydroxymethyl)-4-((4-methoxyphenyl)ethynyl)picolinate (1417730-14-3) + methanesulfonyl chloride (124-63-0) → methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate (1417730-34-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 4 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

4-methoxyphenylacetylen (768-60-5) → methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate (1417730-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0.25 h / 5 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran;

DOI:10.1039/c2cc35247h

Reference yield:

methyl 6-(hydroxymethyl)-4-iodopicolinate (1247012-08-3) → methyl 4-((4-methoxyphenyl)ethynyl)-6-(((methylsulfonyl)oxy)methyl)picolinate (1417730-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0.25 h / 5 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran;

DOI:10.1039/c2cc35247h

upstream raw materials:

methyl 6-(hydroxymethyl)-4-((4-methoxyphenyl)ethynyl)picolinate

methanesulfonyl chloride

4-methoxyphenylacetylen

methyl 6-(hydroxymethyl)-4-iodopicolinate

Downstream raw materials:

C₅₇H₅₄N₆O₉