N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide
CAS No.:639008-10-9
Molecular Formula:C₂₂H₂₇F₃N₂O₅S
Molecular Weight:488.528
Hs Code.:

Synonyms:N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

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Technology Process of N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

There total 10 articles about N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 407-25-0
trifluoroacetic anhydride

: 639008-08-5
2-[4-(2,2-dimethoxyethylamino)phenyl]ethanesulfonic acid benzylmethylamide

: 639008-10-9
N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 19h;
DOI:10.3987/COM-03-9838

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 639008-10-9
N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / t-BuOK / tetrahydrofuran / 4.5 h / -78 °C

2: 82 percent / triethylamine; methanesulfonyl chloride / CHCl₃ / 25.25 h / 0 - 5 °C

3: 0.7 g / NaI*2H₂O / acetone / 6 h / Heating

4: 64 percent / dimethylformamide; SOCl₂ / benzene / 5 h / Heating

5: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C

6: 88 percent / H₂ / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr

7: 84 percent / H₂ / Pd/C / ethanol / 8 h / 20 °C

8: 87 percent / triethylamine / CH₂Cl₂ / 19 h / 0 - 20 °C

With thionyl chloride; potassium tert-butylate; hydrogen; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.3987/COM-03-9838

Reference yield:

: 27238-06-8
N-benzyl-N-methylmethanesulfonamide

: 639008-10-9
N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 4.5 h / -78 °C

2: 85 percent / triethylamine; methanesulfonyl chloride / CH₂Cl₂ / 24.17 h / 0 - 5 °C

3: 88 percent / H₂ / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr

4: 84 percent / H₂ / Pd/C / ethanol / 8 h / 20 °C

5: 87 percent / triethylamine / CH₂Cl₂ / 19 h / 0 - 20 °C

With n-butyllithium; hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;
DOI:10.3987/COM-03-9838