N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

Base Information

Chemical Name:N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide
CAS No.:1312942-02-1
Molecular Formula:C₂₀H₁₀BrF₄N₃O₃S
Molecular Weight:528.281
Hs Code.:

Synonyms:N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

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Chemical Property of N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

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Technology Process of N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

There total 5 articles about N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1312941-98-2
(3-amino-2,6-difluorophenyl)-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1312942-02-1
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 1312941-97-1
{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-carbamic acid methyl ester

: 1312942-02-1
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

2: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

3: pyridine / tetrahydrofuran / 24 h / 20 °C

With pyridine; trimethylsilyl iodide; Dess-Martin periodane; In tetrahydrofuran; acetonitrile;

Reference yield:

: 918521-11-6
[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-carbamic acid methyl ester

: 1312942-02-1
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 24 h / 20 °C

With pyridine; trimethylsilyl iodide; In tetrahydrofuran; acetonitrile;