3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

Base Information

Chemical Name:3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester
CAS No.:1431300-98-9
Molecular Formula:C₂₃H₂₁FN₄O₃S
Molecular Weight:452.509
Hs Code.:

Synonyms:3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

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Chemical Property of 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

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Technology Process of 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

There total 5 articles about 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

: 1431300-95-6
2,2-dimethyl-3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)oxy)propanoic acid methyl ester

: 1431300-97-8
N-(4-bromophenyl)-4-fluorobenzothiazol-2-ylamine

: 1431300-98-9
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 1431300-98-9
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 - 25 °C / Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere; Reflux

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 3.1: |Suzuki Coupling;

Reference yield:

: 65896-11-9
2-bromo-6-fluoroaniline

: 1431300-98-9
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 0.5 h / 18 - 25 °C / Inert atmosphere

1.2: 120 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 2.1: |Suzuki Coupling;