N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Base Information

Chemical Name:N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide
CAS No.:1431648-45-1
Molecular Formula:C₂₀H₁₄F₃N₅O
Molecular Weight:397.359
Hs Code.:

Synonyms:N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Suppliers and Price of N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

There total 7 articles about N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 98-98-6
2-Picolinic acid

: 2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-amine hydrochloride

: 1431648-45-1
N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield: 30.0%

: 98-98-6
2-Picolinic acid

: 5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-amine

: 1431648-45-1
N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 1431654-61-3
benzyl 2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-ylcarbamate

: 1431648-45-1
N-(2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 2.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 50 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; N,N-dimethyl-formamide;