trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine

Base Information

• Chemical Name: trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine
• CAS No.: 128225-20-7
• Molecular Formula: C₁₅H₂₅N₃
• Molecular Weight: 247.384
• Mol file: 128225-20-7.mol

Synonyms:trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine

Chemical Property of trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine

There total 3 articles about trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

7-methyl-7-azabicyclo[4.1.0]heptane (51066-08-1) + 3-(2-methylamino-ethyl)-pyridine (19690-13-2) → trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine (128225-20-7)

Guidance literature:

With ammonium chloride; In water; at 95 - 100 ℃; for 14h;

Reference yield:

pyridyl-3-yl-acetic acid (501-81-5) → trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine (128225-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CH₃OH, HCl / 1.) reflux, 5h, 2.) H₂O, reflux, 3h

2: borane / tetrahydrofuran / 12 h / Heating; addition of borane in 3 steps

3: 49 percent / ammonium chloride / H₂O / 14 h / 95 - 100 °C

With hydrogenchloride; methanol; borane; ammonium chloride; In tetrahydrofuran; water;

Reference yield:

N-methyl-2-pyridin-3-yl-acetamide (106271-65-2) → trans-(+/-)-N,N'-Dimethyl-N-<2-(3-pyridyl)ethyl>-1,2-cyclohexanediamine (128225-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: borane / tetrahydrofuran / 12 h / Heating; addition of borane in 3 steps

2: 49 percent / ammonium chloride / H₂O / 14 h / 95 - 100 °C

With borane; ammonium chloride; In tetrahydrofuran; water;

upstream raw materials:

7-methyl-7-azabicyclo[4.1.0]heptane

3-(2-methylamino-ethyl)-pyridine

pyridyl-3-yl-acetic acid

N-methyl-2-pyridin-3-yl-acetamide