3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Base Information

Chemical Name:3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid
CAS No.:1443255-24-0
Molecular Formula:C₃₃H₃₀ClF₃N₄O₄S
Molecular Weight:671.14
Hs Code.:

Synonyms:3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

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Chemical Property of 3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

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Technology Process of 3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

There total 8 articles about 3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443255-06-8
3-(chloromethyl)-N-[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]benzamide

: 107-96-0
3-mercaptopropionic acid

: 1443255-24-0
3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1441141-76-9
1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole

: 1443255-24-0
3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

2.2: 2 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: 0.33 h / 90 °C

5.1: ammonium chloride; zinc / methanol / 2 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide / 0.25 h / 100 °C / Microwave irradiation

With N-iodo-succinimide; isopropylmagnesium chloride; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; zinc; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

: 1443255-24-0
3-[[3-[[2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]-4-(1-piperidyl)phenyl]carbamoyl]phenyl]methylsulfanyl]propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: 0.33 h / 90 °C

3: ammonium chloride; zinc / methanol / 2 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide / 0.25 h / 100 °C / Microwave irradiation

With ammonium chloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; zinc; In methanol; dichloromethane;