tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

Base Information

Chemical Name:tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate
CAS No.:848155-42-0
Molecular Formula:C₃₅H₅₀N₄O₇
Molecular Weight:638.805
Hs Code.:

Synonyms:tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

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Chemical Property of tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

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Technology Process of tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

There total 4 articles about tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 128422-11-7
N-[(benzyloxy)carbonyl]leucyl-α-aminoisobutyric acid

: 847165-58-6
H-Phe-Aib-O^tBu

: 848155-42-0
tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2004.12.012

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 848155-42-0
tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / N-ethyl-N,N-diisopropylamine; PyAOP / CH₂Cl₂; acetonitrile / 20 h / 20 °C

2: 99 percent / hydrogen / palladium on activated charcoal / methanol / atmospheric pressure

3: 81 percent / N-ethyl-N,N-diisopropylamine; PyAOP / CH₂Cl₂ / 20 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2004.12.012

Reference yield:

: 84758-81-6
2-amino-isobutyric acid tert-butyl ester hydrochloride

: 848155-42-0
tert-butyl N-{N-[N-(N-benzyloxycarbonyl-(S)-leucyl)-2,2-dimethylglycyl]-(S)-phenylalanyl}-2,2-dimethylglycinate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / N-ethyl-N,N-diisopropylamine; PyAOP / CH₂Cl₂; acetonitrile / 20 h / 20 °C

2: 99 percent / hydrogen / palladium on activated charcoal / methanol / atmospheric pressure

3: 81 percent / N-ethyl-N,N-diisopropylamine; PyAOP / CH₂Cl₂ / 20 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2004.12.012