4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl-
• CAS No.: 10376-59-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• DSSTox Substance ID: DTXSID50146043
• Wikidata: Q83010764
• ChEMBL ID: CHEMBL1163483
• Mol file: 10376-59-7.mol

Synonyms:BRN 0158353;4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl-;2-Methyl-3-(beta-hydroxyethyl)-4-quinazolone;10376-59-7;3-(2-Hydroxyethyl)-2-methyl-4(3H)-quinazolinone;5-24-03-00142 (Beilstein Handbook Reference);Oprea1_026491;Oprea1_125421;SCHEMBL3828558;CHEMBL1163483;DTXSID50146043;HMS1585D05;STL361376;AKOS001621044;LS-140948;SR-01000439829;3-(2-Hydroxyethyl)-2-methylquinazolin-4(3H)-one;SR-01000439829-1;Z275210028;3-(2-hydroxyethyl)-2-methyl-3,4-dihydroquinazolin-4-one

Chemical Property of 4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl-

Chemical Property:

• Vapor Pressure: 9.98E-07mmHg at 25°C
• Boiling Point: 388.4°Cat760mmHg
• Flash Point: 188.7°C
• Density: 1.26g/cm³
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 204.089877630
• Heavy Atom Count: 15
• Complexity: 288

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=O)N1CCO

Technology Process of 4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl-

There total 10 articles about 4(3H)-Quinazolinone, 3-(2-hydroxyethyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

2-(2-methyl-4-oxo-3,4-dihydro-3-quinazolinyl)ethyl acetate (879094-46-9) → 3-(2-hydroxyethyl)-2-methyl-quinazoline-(3H)-4-one (10376-59-7)

Guidance literature:

With methanol; water; sodium carbonate; at 20 - 40 ℃; for 4h;

Reference yield: 86.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + ethanolamine (141-43-5) + Triethyl orthoacetate (78-39-7) → 3-(2-hydroxyethyl)-2-methyl-quinazoline-(3H)-4-one (10376-59-7)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.04.083

Reference yield: 82.0%

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)acetamide → 3-(2-hydroxyethyl)-2-methyl-quinazoline-(3H)-4-one (10376-59-7)

Guidance literature:

With water; In acetone; at 100 ℃; for 6h; Green chemistry;

DOI:10.1039/d0ob00881h

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

ethanolamine

o-acetylamino-benzoic acid

2-chloro-ethanol

Downstream raw materials:

3-(2-hydroxyethyl)-2-(2-phenylethenyl)quinazolin-4(3H)-one

3-(2-benzoyloxyethyl)-2-(2-phenylethenyl)quinazolin-4(3H)-one

3-{2-[3-(4-Chloro-phenylamino)-2-hydroxy-propoxy]-ethyl}-2-methyl-3H-quinazolin-4-one

2-phenyl-4(3H)-oxoquinazolin-3-ylethyl chloroacetate

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