N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

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Chemical Name:N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide
CAS No.:1429347-66-9
Molecular Formula:C₄₁H₄₃N₅O₃S
Molecular Weight:685.89
Hs Code.:

Synonyms:N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

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Chemical Property of N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

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Technology Process of N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

There total 6 articles about N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429347-65-8
4-acetyl-N-(2,4-dimethylphenyl)-N-isobutylbenzenesulfonamide

: 178323-88-1
5-methyl-2-trityl-2H-tetrazole

: 1429347-66-9
N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

Guidance literature:: 5-methyl-2-trityl-2H-tetrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -70 ℃; for 0.766667h; Inert atmosphere;

4-acetyl-N-(2,4-dimethylphenyl)-N-isobutylbenzenesulfonamide; In tetrahydrofuran; hexane; at -78 ℃; for 1.01667h;

Reference yield:

: 95-68-1
2,4-Xylidine

: 1429347-66-9
N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] / water / 1 h / 170 °C / Microwave irradiation

2.1: pyridine / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.77 h / -78 - -70 °C / Inert atmosphere

3.2: 1.02 h / -78 °C

With pyridine; n-butyllithium; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium iodide; In tetrahydrofuran; hexane; water;

Reference yield:

: 95-66-9
2,4-dimethylchlorobenzene

: 1429347-66-9
N-(2,4-dimethylphenyl)-4-(2-hydroxy-1-(2-trityl-2H-tetrazol-5-yl)propan-2-yl)-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: {1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinyl}(chloro)(2-methyl-2-propen-1-yl)palladium; lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 70 °C / Inert atmosphere; Sealed tube

2.1: pyridine / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.77 h / -78 - -70 °C / Inert atmosphere

3.2: 1.02 h / -78 °C

With pyridine; n-butyllithium; {1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinyl}(chloro)(2-methyl-2-propen-1-yl)palladium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;