(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Base Information

Chemical Name:(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid
CAS No.:1312952-61-6
Molecular Formula:C₂₉H₃₄N₂O₁₂S
Molecular Weight:634.661
Hs Code.:

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Synonyms:(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

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Chemical Property of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

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Technology Process of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

There total 9 articles about (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1312952-58-1
(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

: 1312952-61-6
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid; With sodium carbonate; In methanol; at 20 - 30 ℃; for 16h;

With acetic acid; In methanol; at 0 - 5 ℃;

Reference yield:

: 61940-21-4
methyl 2-(bromomethyl)-6-nitrobenzoate

: 1312952-61-6
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / N,N-dimethyl-formamide / 24 h / 80 - 90 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 20 h / 2585.81 - 3102.97 Torr / Parr hydrogenation bottle

3.1: trimethylsilyl iodide / 80 °C / Neat (no solvent)

4.1: tetrahydrofuran / 1 h / 60 °C

5.1: boron trifluoride diethyl etherate / dichloromethane / -20 - 20 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 2068.65 - 2327.23 Torr / Parr hydrogenation bottle

7.1: sodium carbonate / methanol / 16 h / 20 - 30 °C

7.2: 0 - 5 °C

With trimethylsilyl iodide; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 635705-76-9
7-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindolin-1-one

: 1312952-61-6
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylsilyl iodide / 80 °C / Neat (no solvent)

2.1: tetrahydrofuran / 1 h / 60 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / -20 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 2068.65 - 2327.23 Torr / Parr hydrogenation bottle

5.1: sodium carbonate / methanol / 16 h / 20 - 30 °C

5.2: 0 - 5 °C

With trimethylsilyl iodide; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;