(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Base Information

Chemical Name:(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid
CAS No.:1312952-58-1
Molecular Formula:C₃₅H₄₀N₂O₁₅S
Molecular Weight:760.773
Hs Code.:

(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Synonyms:(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

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Chemical Property of (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

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Technology Process of (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

There total 8 articles about (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1312952-57-0
(2S,3S,4S,5R,6S)-2-(benzyloxycarbonyl)-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 1312952-58-1
(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 4h; under 2068.65 - 2327.23 Torr; Parr hydrogenation bottle;

Reference yield:

: 608141-42-0
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

: 1312952-58-1
(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / N,N-dimethyl-formamide / 24 h / 80 - 90 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 20 h / 2585.81 - 3102.97 Torr / Parr hydrogenation bottle

3: trimethylsilyl iodide / 80 °C / Neat (no solvent)

4: tetrahydrofuran / 1 h / 60 °C

5: boron trifluoride diethyl etherate / dichloromethane / -20 - 20 °C

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 2068.65 - 2327.23 Torr / Parr hydrogenation bottle

With trimethylsilyl iodide; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 61940-21-4
methyl 2-(bromomethyl)-6-nitrobenzoate

: 1312952-58-1
(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-(4-((S)-1-(7-(cyclopropanecarboxamido)-1-oxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)tetrahydro-2H-pyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / N,N-dimethyl-formamide / 24 h / 80 - 90 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 20 h / 2585.81 - 3102.97 Torr / Parr hydrogenation bottle

3: trimethylsilyl iodide / 80 °C / Neat (no solvent)

4: tetrahydrofuran / 1 h / 60 °C

5: boron trifluoride diethyl etherate / dichloromethane / -20 - 20 °C

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 2068.65 - 2327.23 Torr / Parr hydrogenation bottle

With trimethylsilyl iodide; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;