(4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

Base Information

Chemical Name:(4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one
CAS No.:397-62-6
Molecular Formula:C16H10 F N O2
Molecular Weight:267.259
Hs Code.:
European Community (EC) Number:206-908-5
NSC Number:74502
ChEMBL ID:CHEMBL1992717
Mol file:397-62-6.mol

Synonyms:(4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one;(4Z)-4-[(3-fluorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one;397-62-6;5(4H)-Oxazolone,4-[(3-fluorophenyl)methylene]-2-phenyl-;NSC74502;5(4H)-Oxazolone, 4-((3-fluorophenyl)methylene)-2-phenyl-;CHEMBL1992717;WLN: T5NYVOJ BU1R CF& ER;NSC-74502;STL482292;AKOS000516128;SR-01000417457;SR-01000417457-1;Z31309277

Suppliers and Price of (4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of (4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

Chemical Property:

Vapor Pressure:3.76E-06mmHg at 25°C
Boiling Point:385.6°Cat760mmHg
Flash Point:187°C
PSA：38.66000
Density:1.23g/cm³
LogP:2.60580
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:267.06955672
Heavy Atom Count:20
Complexity:438

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC(=CC3=CC(=CC=C3)F)C(=O)O2
Isomeric SMILES:C1=CC=C(C=C1)C2=N/C(=C\C3=CC(=CC=C3)F)/C(=O)O2

Technology Process of (4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one

There total 3 articles about (4Z)-4-(3-fluorobenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1199-01-5,53766-22-6
2-phenylazlactone

: 456-48-4
3-Fluorobenzaldehyde

: 397-62-6
4-(3-fluorobenzylidene)-2-phenyloxazol-5-one

Guidance literature:: With aluminum oxide; In chloroform; at 20 ℃;
DOI:10.1016/j.tet.2009.02.011

Reference yield:

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 456-48-4
3-Fluorobenzaldehyde

: 397-62-6
4-(3-fluorobenzylidene)-2-phenyloxazol-5-one

Guidance literature:: Hippuric Acid; With chloroformic acid ethyl ester; triethylamine; In toluene; at 5 - 10 ℃; for 0.5h;

3-Fluorobenzaldehyde; With triethylamine; In toluene; at 5 ℃;
DOI:10.1002/cbdv.202000014

Reference yield:

: 98-88-4
benzoyl chloride

: 397-62-6
4-(3-fluorobenzylidene)-2-phenyloxazol-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 2 h / Cooling with ice

2.1: chloroformic acid ethyl ester; triethylamine / toluene / 0.5 h / 5 - 10 °C

2.2: 5 °C

With chloroformic acid ethyl ester; triethylamine; sodium hydroxide; In toluene;
DOI:10.1002/cbdv.202000014