(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

Base Information

Chemical Name:(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate
CAS No.:258876-06-1
Molecular Formula:C₃₄H₃₀NO₇PS
Molecular Weight:627.654
Hs Code.:

Synonyms:(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

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Chemical Property of (1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

Chemical Property:

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Technology Process of (1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

There total 7 articles about (1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3696-28-4
2,2'-dipyridyl disulfide bis-N-oxide

: 3-(diphenoxy-phosphoryloxy)-2-(4-methoxy-phenyl)-2-methyl-3-phenyl-propionic acid

: 258876-06-1
(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

Guidance literature:: With tributylphosphine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo991570o

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 258876-06-1
(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 94 percent / HMPA / tetrahydrofuran / 1.5 h / -78 °C

3.1: n-BuLi; hexamethyldisilamine / tetrahydrofuran / -78 °C

3.2: tetrahydrofuran / -78 - -20 °C

4.1: CAN / acetonitrile; H₂O / 1 h / 20 °C

5.1: n-Bu₃P / CH₂Cl₂ / 20 °C

With dmap; n-butyllithium; ammonium cerium(IV) nitrate; tributylphosphine; dicyclohexyl-carbodiimide; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.1: Esterification / 2.1: Metallation / 2.2: Addition / 3.1: aldol condensation / 3.2: phosphorylation / 4.1: oxidative cleavage / 5.1: Esterification;
DOI:10.1021/jo991570o

Reference yield:

: 100-52-7
benzaldehyde

: 258876-06-1
(1H)-2-thioxo-1-pyridyl 3-(diphenylphosphatoxy)-2-methyl-2-(4-methoxyphenyl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; hexamethyldisilamine / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - -20 °C

2.1: CAN / acetonitrile; H₂O / 1 h / 20 °C

3.1: n-Bu₃P / CH₂Cl₂ / 20 °C

With n-butyllithium; ammonium cerium(IV) nitrate; tributylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.1: aldol condensation / 1.2: phosphorylation / 2.1: oxidative cleavage / 3.1: Esterification;
DOI:10.1021/jo991570o