3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester

Base Information

• Chemical Name: 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester
• CAS No.: 808139-43-7
• Molecular Formula: C₂₁H₂₉Cl₂N₃O₇S₂Si
• Molecular Weight: 598.601
• Mol file: 808139-43-7.mol

Synonyms:3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester

Chemical Property of 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester

There total 5 articles about 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-N-[3-methoxy-5-[[2-(4-pyridinyl)ethyl]thio]pyrazin-2-yl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide (808139-26-6) + methyl (2S)-glycidate (4538-50-5,85485-00-3,111058-32-3,118712-39-3) → 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester (808139-43-7)

Guidance literature:

2,3-dichloro-N-[3-methoxy-5-[[2-(4-pyridinyl)ethyl]thio]pyrazin-2-yl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide; With potassium tert-butylate; In tetrahydrofuran; for 0.5h;

methyl (2S)-glycidate; In tetrahydrofuran; for 20h;

Reference yield:

2,3-dichloro-N-(5-chloro-3-methoxypyrazin-2-yl)-N-[[2-(trimethylsilyl)ethoxy]methyl]benzenesulfonamide (566204-86-2) → 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester (808139-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / acetonitrile / 24 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 20 h

With potassium tert-butylate; caesium carbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide (566203-62-1) → 3-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-(2R)-2-hydroxypropanoic acid methyl ester (808139-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.1: caesium carbonate / acetonitrile / 24 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

3.2: 20 h

With potassium tert-butylate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

2,3-dichloro-N-[3-methoxy-5-[[2-(4-pyridinyl)ethyl]thio]pyrazin-2-yl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide

methyl (2S)-glycidate

2,3-dichloro-N-(5-chloro-3-methoxypyrazin-2-yl)-N-[[2-(trimethylsilyl)ethoxy]methyl]benzenesulfonamide

2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide