2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide

Base Information

• Chemical Name: 2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide
• CAS No.: 566203-62-1
• Molecular Formula: C11H8Cl3N3O3S
• Molecular Weight: 368.62400
• DSSTox Substance ID: DTXSID60437919
• Wikidata: Q82253525
• Pharos Ligand ID: BRN3FYZVSBHA
• ChEMBL ID: CHEMBL4165939
• Mol file: 566203-62-1.mol

Synonyms:566203-62-1;CHEMBL4165939;2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide;2,3-Dichloro-N-(5-chloro-3-methoxypyrazin-2-yl)benzenesulfonamide;SCHEMBL1732492;DTXSID60437919;QOOFDNFFMVSLIZ-UHFFFAOYSA-N;BDBM50278786;2,3-Dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide

Chemical Property of 2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide

Chemical Property:

• PSA: 92.79000
• LogP: 3.74890
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 366.935195
• Heavy Atom Count: 21
• Complexity: 448

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=CN=C1NS(=O)(=O)C2=C(C(=CC=C2)Cl)Cl)Cl

Technology Process of 2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide

There total 2 articles about 2,3-Dichloro-N-(5-chloro-3-methoxypyrazinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide (566203-96-1) + sodium methylate (124-41-4) → 2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide (566203-62-1)

Guidance literature:

2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide; sodium methylate; In methanol; for 24h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

dichlorobenzenesulfonyl chloride (82417-45-6) → 2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide (566203-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane / 1 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: methanol / 24 h / Heating / reflux

With sodium hydride; In methanol; 1,2-dimethoxyethane;

Reference yield:

2,3-dichloro-N-(5-chloro-3-methoxy-2-pyrazinyl)benzenesulphonamide (566203-62-1) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 2,3-dichloro-N-(5-chloro-3-methoxypyrazin-2-yl)-N-[[2-(trimethylsilyl)ethoxy]methyl]benzenesulfonamide (566204-86-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide

sodium methylate

dichlorobenzenesulfonyl chloride

Downstream raw materials:

2,3-dichloro-N-(5-chloro-3-methoxypyrazin-2-yl)-N-[[2-(trimethylsilyl)ethoxy]methyl]benzenesulfonamide

2,3-dichloro-N-[3-methoxy-5-[[(trimethylsilyl)methyl]thio]pyrazin-2-yl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-benzenesulfonamide

2-[[5-[[(2,3-dichlorophenyl)sulfonyl][[2-(trimethylsilyl)ethoxy]methyl]amino]-6-methoxypyrazin-2-yl]thio]-N-methoxy-N-methyl-acetamide