Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis-

Base Information

Chemical Name:Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis-
CAS No.:67450-78-6
Molecular Formula:C₁₆H₂₂Cl₂N₂O
Molecular Weight:329.269
Hs Code.:
DSSTox Substance ID:DTXSID001136933

Synonyms:DCDPP;N-(2-(dimethylamino)cyclopentyl)-N-(3,4-dichlorophenyl)propanamid;U 78753E;U 78753E maleate;U 78753E, ethanedioate salt (1:1), (cis)-isomer;U-78753E

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis-

Chemical Property:

Boiling Point:443.5°Cat760mmHg
Flash Point:222.1°C
Density:1.22g/cm³
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:328.1109187
Heavy Atom Count:21
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N(C1CCCC1N(C)C)C2=CC(=C(C=C2)Cl)Cl
Isomeric SMILES:CCC(=O)N([C@@H]1CCC[C@@H]1N(C)C)C2=CC(=C(C=C2)Cl)Cl

Technology Process of Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis-

There total 10 articles about Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 285-67-6
Cyclopentene oxide

: 67450-44-6,67450-78-6,67451-05-2,67451-07-4,71027-13-9
N--N-(3,4-dichlorophenyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: concd. HCl / 168 h / Heating

2: 72 h / Heating

3: 85percent aq. ethanolic KOH / 3 h / Ambient temperature

4: CrO₃, aq. H₂SO₄ / acetone / 0.5 h / Ambient temperature

5: 4.2 g / dimethylamine hydrochloride, NaCNBH₃ / methanol / 192 h / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; potassium hydroxide; sulfuric acid; N,N-dimethylammonium chloride; sodium cyanoborohydride; In methanol; acetone;
DOI:10.1021/jm00142a020

Reference yield:

: 285-67-6
Cyclopentene oxide

: 67450-44-6,67450-78-6,67451-05-2,67451-07-4,71027-13-9
N--N-(3,4-dichlorophenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂O

2: 1.) NaH / 1.) THF, reflux, 1 h

3: 2.) 20percent NaOH / 1.) reflux, 17 h, 2.) 1 h

4: Heating

With sodium hydroxide; sodium hydride; In water;
DOI:10.1021/jm00142a020

Reference yield:

: 67440-15-7,70527-37-6
N-(trans-2-hydroxycyclopentyl)-N-(3,4-dichlorophenyl)propanamide

: 67450-44-6,67450-78-6,67451-05-2,67451-07-4,71027-13-9
N--N-(3,4-dichlorophenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: CrO₃, aq. H₂SO₄ / acetone / 0.5 h / Ambient temperature

2: 4.2 g / dimethylamine hydrochloride, NaCNBH₃ / methanol / 192 h / Ambient temperature

With chromium(VI) oxide; sulfuric acid; N,N-dimethylammonium chloride; sodium cyanoborohydride; In methanol; acetone;
DOI:10.1021/jm00142a020