1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene

Base Information

• Chemical Name: 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene
• CAS No.: 1239333-60-8
• Molecular Formula: C₁₆H₂₃ClO₄Si
• Molecular Weight: 342.895

Synonyms:1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene

Chemical Property of 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene

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Technology Process of 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene

There total 2 articles about 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloro-trimethyl-silane (75-77-4) + 1-chloro-3-ethynyl-2,5-dimethoxy-4-((methoxymethoxy)methyl)-benzene (1239333-59-5) → 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene (1239333-60-8)

Guidance literature:

1-chloro-3-ethynyl-2,5-dimethoxy-4-((methoxymethoxy)methyl)-benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1021/jo100913s

Reference yield: 91.0%

3-bromo-1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-benzene (1239333-57-3) + (trimethylsilylethynyl)tributyltin (81353-38-0) → 1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene (1239333-60-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 20 - 115 ℃; Inert atmosphere;

DOI:10.1021/jo100913s

Reference yield: 92.0%

1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)benzene (1239333-60-8) → 5-chloro-2-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)-1,4-benzoquinone (1239333-55-1)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; Inert atmosphere;

DOI:10.1021/jo100913s

upstream raw materials:

chloro-trimethyl-silane

1-chloro-3-ethynyl-2,5-dimethoxy-4-((methoxymethoxy)methyl)-benzene

3-bromo-1-chloro-2,5-dimethoxy-4-((methoxymethoxy)methyl)-benzene

(trimethylsilylethynyl)tributyltin

Downstream raw materials:

5-chloro-2-((methoxymethoxy)methyl)-3-((trimethylsilyl)ethynyl)-1,4-benzoquinone

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