(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Base Information

Chemical Name:(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine
CAS No.:146499-49-2
Molecular Formula:C₂₂H₃₁NO₃SSi
Molecular Weight:417.645
Hs Code.:

Synonyms:(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Suppliers and Price of (2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

There total 8 articles about (2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 146499-59-4
(2R,3S)-N-p-toluenesulfonyl-3-hydroxy-2-phenylazetidine

: 146499-49-2
(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1016/S0040-4039(00)74779-4 DOI:10.1016/S0040-4020(01)80749-3

Reference yield: 75.0%

: 146499-48-1
(2R,3R)-2-tert-butyldimethylsiloxy-3-phenyl-3-p-toluenesulfonylamino-1-p-toluenesulfonylpropane

: 146499-59-4
(2R,3S)-N-p-toluenesulfonyl-3-hydroxy-2-phenylazetidine

: 146499-49-2
(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Guidance literature:: With methanol; sodium hydride; for 11h; Ambient temperature;
DOI:10.1016/S0040-4039(00)74779-4

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 146499-49-2
(2R,3S)-N-p-toluenesulfonyl-3-tert-butyldimethylsiloxy-2-phenylazetidine

Guidance literature:: Multi-step reaction with 6 steps

1: 398 mg / Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: imidazole / dimethylformamide / 19 h / Ambient temperature

3: 1.33 g / 5percent Pd-C, HCO₂NH₄ / methanol / 1 h / Ambient temperature

4: Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

5: 18 percent / NaH / methanol / 11 h / Ambient temperature

6: 99 percent / imidazole / dimethylformamide / 3 h / 50 °C

With 1H-imidazole; dmap; palladium on activated charcoal; ammonium formate; sodium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80749-3