Technology Process of N-benzyl-2-((4-methoxyphenyl)ethynyl)aniline
There total 10 articles about N-benzyl-2-((4-methoxyphenyl)ethynyl)aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
at 20 ℃;
for 1h;
- Guidance literature:
-
benzaldehyde; 2-((4-methoxyphenyl)ethynyl)aniline;
With
trifluoroacetic acid;
In
Isopropyl acetate;
at 20 ℃;
Inert atmosphere;
With
sodium tris(acetoxy)borohydride;
In
Isopropyl acetate;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jacs.6b08925
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 1 h / 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / Isopropyl acetate / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; Isopropyl acetate;
1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling / 3.1: |Sonogashira Cross-Coupling / 3.2: |Sonogashira Cross-Coupling;
DOI:10.1021/jacs.6b08925
